Lipo-C + B12

• **Lipotropic factors** — usually methionine, inositol and choline, referred to by the abbreviation MIC.
• **Cyanocobalamin or methylcobalamin** (vitamin B12).
• The exact composition and concentrations are given in the certificate of analysis for the batch; formulations differ between manufacturers.
• **It is not a peptide.** It is a mixture of an amino acid, B-group vitamins and vitamin B12.

• Choline and methionine are described in the literature as methyl group donors in lipid metabolism.
• Inositol is part of the phosphatidylinositol signalling pathways.
• B12 is a cofactor of methionine synthase and methylmalonyl-CoA mutase — so it feeds into the same methylation cycle.
• The combination is built on the shared involvement of these substances in methylation metabolism, not on a demonstrated synergistic effect.

• Lipid metabolism and fat transport in the liver.
• The methylation cycle and homocysteine.
• Nutritional deficiencies of B-group vitamins.

The individual components have well described biochemistry and, in the case of

B12 deficiency, clinical data as well. The combined formulation as a whole,

however, has no controlled studies, and claims about an effect on body

composition are not supported.

• Supplied as a ready solution — it is not reconstituted.
• Light sensitive; B12 degrades on exposure to light. Keep in the dark and cold.
• Do not freeze.