Description
- A peptide analogue of amylin — the hormone the beta cells of the pancreas secrete alongside insulin.
- Human amylin tends to aggregate into fibrils; the sequence here is deliberately modified so that the molecule stays soluble.
- A fatty acid chain attached to a lysine keeps it bound to albumin, which in studies extends how long it stays in circulation.
- Unlike the incretin analogues (GLP-1, GIP) it does not act on incretin receptors — this is a separate pathway that the literature combines with them.
- Supplied as a lyophilised powder for reconstitution.
- Published work describes binding to amylin receptors, which are formed by the calcitonin receptor in complex with the RAMP1–RAMP3 proteins.
- Signalling is described in the brainstem — the area postrema and the nucleus tractus solitarii — that is, outside the blood-brain barrier.
- In models it is associated with slowed gastric emptying and with suppressed food intake through a satiety signal.
- The amylin pathway is distinct from the incretin pathway, so their combined action is a research branch of its own.
- Satiety signalling and the regulation of food intake.
- Body weight and body composition in metabolic models.
- Gastric emptying.
- Combined action of the amylin and incretin pathways.
Cagrilintide is under active clinical investigation and development is still under way for every indication being studied. The amylin pathway is younger in metabolic research than the incretin pathway and less data is available. What does exist comes from clinical trials with defined dosing, monitoring and participant selection, and applies to the conditions it comes from.
Cagrilintide is a pharmacologically active substance with the character of a drug substance. This item is a reference standard intended strictly for laboratory and research use. It is not a medicine, it is not authorised for administration to humans, and it must not be used for diagnosis, prevention or treatment. We provide no dosing, protocols or health advice. The purchaser is responsible for complying with the law in force at the place of delivery and for safe handling in line with laboratory practice.
NOT FOR CONSUMPTION. FOR RESEARCH USE ONLY. Reference material intended solely for laboratory and research use. It is not a medicine, food supplement, food or cosmetic product, and it is not intended for diagnosis, treatment, ingestion, inhalation, injection or any other administration to humans or animals. The information below summarises published research; it is not a claim about this article and not instructions for use. We provide no dosage or health guidance.
